This Quick Help has provided several ways that you can try to fix the issue.
It only happens on some PCs and we don't have a fix for this yet. Usually the message is There is a problem sending the command to the program. This issue started since Windows Vista and on and not unique to Origin. If you are receiving "System Folder Build Failed", "X-Function failed to execute" error messages when starting Origin, you can refer to this Quick Help page for solutions.Please refer to this Quick Help page for solutions. If you are receiving missing DLL error messages when starting Origin, it means the required Microsoft DLLs by Origin are missing on your computer.Output Error Messages When Starting Origin To determine whether the network makes Origin slow to open in such case, try to break from network temporarily or borrow a license from server and then restart Origin, see if it starts faster. If you have a Concurrent license and the Flexnet server locates far away (for example in another country), or in a network very slow to connect, Origin operation would heavily rely on the network status.
Output Error Messages When Trying to Install Origin This Quick Help page provides a general routine to help users to self-diagnose the problem of Origin resulted from unknown reasons. 5.44 FAQ-780 What should I do when Origin does not function for unknown reasons?